TY - JOUR T1 - Topical diltiazem for pain after closed hemorrhoidectomy JO - Revista de Gastroenterología de México T2 - AU - Rodríguez-Wong,U. AU - Ocharán-Hernández,M.E. AU - Toscano-Garibay,J. SN - 2255534X M3 - 10.1016/j.rgmxen.2016.03.003 DO - 10.1016/j.rgmxen.2016.03.003 UR - http://www.revistagastroenterologiamexico.org/en-topical-diltiazem-for-pain-after-articulo-S2255534X16000128 AB - BackgroundAnal sphincter spasm contributes to the appearance of postoperative pain following hemorrhoidectomy. AimTo determine the efficacy of topical diltiazem in the control of post-hemorrhoidectomy pain. Material and methodsA randomized, prospective, experimental, double-blind study was conducted on 2 groups of patients in the postoperative period of closed hemorrhoidectomy. Each group consisted of 17 patients. Group A received topical diltiazem in the anal region 3 times a day and group B received a placebo. Ketorolac was administered to both groups as rescue therapy. ResultsIn group A, the mean score on the visual analog scale was 2.97±1.18cm at 24h, 1.51±1.18cm at 48h, and 0.84±0.92cm at 72h. In group B, it was 6.82±1.9cm at 24h, 5.3±1.66cm at 48h, and 4.32±2.13cm at 72h (P<.001, 95% CI).The mean number of analgesic doses in group A was 2.41±0.87 at 24h, 1.11±0.85 at 48h, and 0.94±0.96 at 72h. In group B, it was 3.82±0.52 at 24h, 3.64±0.70 at 48h, and 2.88±1.26 at 72h (P<.001, 95% CI). ConclusionsIn this study, topical administration of diltiazem resulted in a statistically significant reduction of postoperative pain in patients that underwent closed hemorrhoidectomy. ER -