TY - JOUR T1 - Genetic polymorphisms of interleukin-22 in patients with ulcerative colitis JO - Revista de Gastroenterología de México T2 - AU - Yamamoto-Furusho,J.K. AU - Sánchez-Morales,G.E. AU - García-Rangel,D. AU - Vargas-Alarcón,G. SN - 2255534X M3 - 10.1016/j.rgmxen.2016.02.006 DO - 10.1016/j.rgmxen.2016.02.006 UR - http://www.revistagastroenterologiamexico.org/en-genetic-polymorphisms-interleukin-22-in-patients-articulo-S2255534X16000141 AB - BackgroundUlcerative colitis (UC) is a multifactorial and polygenic disease. Interleukin-22 (IL-22) is an immunomodulatory cytokine that belongs to the IL-10 family. Currently, some IL-22 polymorphisms have been associated with inflammatory processes such as rheumatoid arthritis and psoriasis vulgaris, but there are no studies on UC. AimThe aim of this work was to study the frequency of polymorphisms of IL-22 in Mexican patients with UC. MethodsWe studied a total of 199 Mexican patients with confirmed UC and 697 healthy controls. All individuals were born in Mexico, at least three family generations earlier. A blood sample was obtained from the UC patients and healthy controls in order to perform DNA extraction and then to determine the frequency of IL-22 polymorphisms (rs2227485, rs2272478, rs2227491). ResultsNo statistical significance was found in the gene and genotype frequencies of three SNPs of IL-22 (rs2227485, rs2272478, rs2227491) between the UC patients and healthy controls. No association was found between those IL-22 SNPs and clinical features of UC. ConclusionsThere was no association between IL-22 SNPs (rs2227485, rs2272478, rs2227491) and the development of UC in a Mexican population. ER -