TY - JOUR T1 - Production of insulin-like growth factor-binding proteins during the development of hepatic fibrosis due to chronic hepatitis C JO - Revista de Gastroenterología de México T2 - AU - Rosique-Oramas,D. AU - Martínez-Castillo,M. AU - Raya,A. AU - Medina-Ávila,Z. AU - Aragón,F. AU - Limón-Castillo,J. AU - Hernández-Barragán,A. AU - Santoyo,A. AU - Montalvo-Javé,E. AU - Pérez-Hernández,J.L. AU - Higuera-de la Tijera,F. AU - Torre,A. AU - Kershenobich,D. AU - Gutiérrez-Reyes,G. SN - 2255534X M3 - 10.1016/j.rgmxen.2019.08.002 DO - 10.1016/j.rgmxen.2019.08.002 UR - http://www.revistagastroenterologiamexico.org/en-production-insulin-like-growth-factor-binding-proteins-articulo-S2255534X20300013 AB - Introduction and AimsInsulin-like growth factor 1 is modulated by the insulin-like growth factor-binding proteins (IGFBPs) that are synthesized in the liver. The aim of the present study was to evaluate the concentrations of IGFBPs 1–7 in patients with chronic hepatitis C and study their association with fibrosis stage. Patients and methodsA prospective, cross-sectional study was conducted that included patients with chronic hepatitis C. The stages of fibrosis were determined through FibroTest and FibroScan and the patients were compared with a control group. Serum levels of IGFBPs 1–7 were quantified through multiple suspension arrays. The Kruskal-Wallis test, Mann-Whitney U test, Spearman’s correlation, and ROC curves were used for the statistical analysis. ResultsUpon comparing the patients and controls, the highest concentrations were found in IGFBPs 1, 2, 4, and 7 (p=0.02, 0.002, 0.008, and <0.001, respectively). IGFBP-3 levels had a tendency to be lower in the patients (p=0.066), whereas values were similar between patients and controls for IGFBP-5 and 6 (p=0.786 and p=0.244, respectively). Of the seven IGFBPs, IGFBP-3 concentrations were the highest. There were significant differences between fibrosis stages for IGFBP-5 and IGFBP-7. ConclusionIGFBPs play a relevant role in the fibrotic process in liver damage. IGFBP-7, in particular, differentiates fibrosis stages, making it a potential serum biomarker. ER -