Systemic hypertensionRelation of Microalbuminuria to Adiponectin and Augmented C-Reactive Protein Levels in Men With Essential Hypertension
Section snippets
Study participants
The study population consisted of 149 consecutive men who had newly diagnosed (within the previous 2 years), untreated stage I/II essential hypertension, were 30 to 65 years of age, and were referred or self-referred to the outpatient hypertension unit within a period of 6 months.13 Secondary forms of hypertension were excluded according to established diagnostic methods.13, 14
Exclusion criteria included heart failure, atherosclerotic cardiovascular disease, diabetes mellitus or glucose
Results
Subjects who had hypertension (n = 108) compared with controls (n = 110) did not differ with regard to age, BMI, waist-to-hip ratio, lipid profile, hemoglobin A1c, and fasting glucose levels (p = NS for all cases) but exhibited a higher ACR (by 9.65 mg/g, p <0.0001), log hs-CRP levels (by 0.14 mg/L, p <0.0001), greater left ventricular mass index (107 ± 12 vs 96 ± 14 g/m2, p <0.05), and greater relative wall thickness (0.41 ± 0.07 vs 0.38 ± 0.02, p <0.05). There was also a trend toward lower
Discussion
The main finding of our study is that an inverse relation exists between ACR and adiponectin, a novel circulating antiatherogenic adipose-specific protein, in men who are newly diagnosed with essential hypertension. Moreover, microalbuminuria is accompanied not only by increased levels of an established inflammatory marker, such as hs-CRP, but also by attenuated levels of adiponectin in this setting.
In our study, subjects who had hypertension compared with controls exhibited a trend toward
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