Original articleVertebral Fractures and Role of Low Bone Mineral Density in Crohn’s Disease
Section snippets
Study Participants
Two hundred twenty-four consecutively encountered patients who had either active or quiescent CD and who were attending the Inflammatory Bowel Disease Referral Clinic at the University of Alberta Hospital (Edmonton, Alberta, Canada) were identified as possible experiment participants between September 2000–July 2001. They completed a questionnaire documenting age, CD diagnosis date, gender, smoking status, and number of flare-ups requiring a visit to the physician and/or corticosteroid use
Patient Characteristics
Descriptive statistics for 224 patients enrolled in this study are outlined in Table 1. Fifty-six percent of the study population was female, and 23% was postmenopausal. The average age of the study population was 38.7 ± 11.8 years. Approximately fifty percent of the group reported corticosteroid use during the year preceding enrollment in the current study. The median lumbar spine T score was −0.71 (25th percentile, −1.47; 75th percentile, −0.07). Median T scores (25th and 75th percentiles)
Discussion
For this study, radiologic assessment of vertebral fractures was performed in a blinded fashion by investigators experienced in such assessments. Each of the 2 methods of assessment (quantitative morphometry and semiquantitative SFI) was performed independently by different investigators. The SFI was chosen as the primary method of vertebral fracture determination. This assessment technique, based on the Genant semiquantitative method, is both highly sensitive and specific in the hands of
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2013, Journal of Crohn's and ColitisCitation Excerpt :The presence of osteoporosis is one (but not the only) risk factor for fractures of the spine and peripheral long bones. In recent studies, vertebral fractures have been documented in patients with both reduced and normal bone density; challenging the concept that osteoporosis is the main risk factor for vertebral fractures in young patients with IBD.254–256 The strongest predictor of future fracture is a prior vertebral fracture.
Risedronate improves bone mineral density in Crohn's disease: A two year randomized controlled clinical trial
2012, Journal of Crohn's and ColitisCitation Excerpt :Yet there has been discordance in fracture risk with low bone mineral density. Vertebral fractures have occurred in Crohn's disease patients with normal as well as low bone mineral density.33 The effect on fracture risk from treatment of non-osteoporotic low bone mineral density in Crohn's disease patients is currently unknown.
Supported by Crohn’s and Colitis Foundation of Canada the Cecile Mactaggart Summer Studentship Program and an Unrestricted Research Grant from Proctor and Gamble Pharmaceuticals, Canada.