Clinics and Research in Hepatology and Gastroenterology
Mini reviewCeliac disease in children
Section snippets
Definition
Celiac disease (CD) is an immune-mediated enteropathy, induced by gluten ingestion in genetically predisposed individuals. Gluten is the major protein component of wheat, barley and rye that are widely consumed cereals in most countries of the world. Gluten sensitivity in CD is due to an abnormal cellular immune response responsible of a villous atrophy, which resolves under gluten-free diet.
Historical
Symptoms of CD were first described by a Greek physician, Aretee de Cappadoce, in the first century.
Conclusion
Prevalence of CD has dramatically increased in the last two decades due to the use of serological tests. Only 10% of children having CD are symptomatic. A large part of asymptomatic patients remains undiagnosed, even if screening CD is now recommended in at risk groups, especially children having type 1 diabetes or in a context of a family history of CD. The typical clinical picture of malabsorptive syndrome remains frequent in young infant, but milder intestinal symptoms and extra-digestive
Disclosure of interest
The authors declare that they have no conflicts of interest concerning this article.
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Serological screening for coeliac disease in patients with juvenile idiopathic arthritis
2019, Arab Journal of GastroenterologyCitation Excerpt :Symptomatic patients represent only 10% of CD patients. Even if screening for CD is recommended in high risk groups, usually a majority of asymptomatic patients still remain undiagnosed [23]. It can be difficult to diagnose CD in systemic rheumatic diseases because these are often associated with a number of gastrointestinal symptoms and diseases [24].
Clinical guidelines on the diagnosis and treatment of celiac disease in Mexico
2018, Revista de Gastroenterologia de MexicoBeyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease
2023, Journal of Clinical MedicineSerological Screening for Celiac Disease and Gastrointestinal Absorption Disorders in Patients with Autoimmune Endocrine Diseases
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2023, International Journal of Pharmaceutical Quality AssuranceCeliac Disease Screening in the Siblings of Pediatric Patients with a Confirmed Diagnosis: A Cross-sectional Study
2023, Journal of Comprehensive Pediatrics