Original articleClinical endoscopyNarrow-band imaging as an alternative to chromoendoscopy for the detection of dysplasia in long-standing inflammatory bowel disease: a prospective, randomized, crossover study
Section snippets
Patients
Consecutive patients with clinically inactive, long-standing UC (≥8 years) involving at least the left colon or patients with colonic Crohn's disease (CD) affecting at least one third of the colon (≥8 years) were recruited from the Outpatient Clinic of the Gastroenterology Department at Hospital Clinic, Barcelona, Spain. Patients were excluded if they had previous colorectal cancer, a previous surgical resection of the colon or rectum, coagulopathy, a known allergy to indigo carmine, or if they
Patient characteristics
Between April 2006 and November 2007, a total of 80 patients fulfilled inclusion criteria and were enrolled in this study. Twenty patients had to be excluded from further analysis because either 1 or both procedures was incomplete because of poor or fair bowel preparation (n = 6), endoscopic activity (n = 11), or lack of agreement (n = 3) (Fig. 1). Our analysis was therefore restricted to 60 patients for whom paired colonoscopic procedural data were available. CE was the first study performed
Discussion
To our knowledge, this is the first prospective, randomized study to compare the effectiveness of NBI compared with CE for the detection of IN in patients with long-standing colonic IBD. In this study, we provide evidence supporting the use of NBI as a novel method for detecting dysplasia in this patient population.
In this series, we included patients with extensive colonic CD as well as individuals with UC. In both cases, only lesions located in colitic areas were considered. Interestingly,
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DISCLOSURE: The following author disclosed a financial relationship relevant to this publication: Cristina Rodríguez de Miguel is a research nurse supported by Olympus Medical Systems, Europe. The other authors disclosed no financial relationships relevant to this publication. This work was supported in part by grants from the Fondo de Investigaciones Sanitarias (FIS Proyectos de Evaluación de Tecnologías Sanitarias PI07/90174- M.P). Maria López Cerón is a research fellow from the FIS (Rio Hortega contract). The Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) is funded by the Instituto de Salud Carlos III. Prototype endoscopic equipment was supplied by Olympus Medical Systems, Europe.
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