Systematic review and meta-analysisRetention associated with video capsule endoscopy: systematic review and meta-analysis
Section snippets
Background
Video capsule endoscopy (VCE) has become a major diagnostic tool for the evaluation of small bowel disorders since its introduction to the scientific community via Nature in 2000.1 This is in part due to the fact that other techniques for evaluation of the small bowel, including radiography, scintigraphy, operative enteroscopy, push enteroscopy, and double-balloon enteroscopy, are either insensitive, time-consuming, invasive and/or not widespread.2
Advantages associated with usage of VCE have
Literature search
By using key search terms of capsule endoscopy and retention (Appendix 1, available online at www.giejournal.org), we performed a comprehensive literature search from 1995 to 2015 by using Pubmed (N = 243) and SCOPUS (N = 314). We included cohort studies (both retrospective and prospective) that enrolled at least 10 patients undergoing video capsule endoscopy (VCE) for any indication including suspected small-bowel bleeding, suspected or known inflammatory bowel disease (IBD), suspected
Results
The search resulted in 557 references initially, 269 of which were related to VCE. We excluded 202 publications that were not related to the topic of VCE retention, included pediatric patients, were not published in English, or were case reports and/or review articles. Of the 67 remaining articles, 10 were excluded for using patency capsules and 6 for not separating capsule retention rate by indication. In addition, 6 more articles were excluded that were abstracts for which the full
Discussion
VCE has become a common diagnostic tool used for the evaluation of small-bowel disorders, especially small-bowel bleeding and suspected or established Crohn’s disease. However, capsule retention is a rare but potentially serious adverse event. Rates of retention for various indications for the capsule endoscopy vary in the literature, with GI bleeding rates commonly cited around 2% and Crohn’s disease as high as 13%.46
In our analysis, the rates of capsule retention associated with occult and/or
References (77)
- et al.
A guideline for reviewing a clinical research paper
Gastrointest Endosc
(2015) - et al.
Performance of the patency capsule compared with nonenteroclysis radiologic examinations in patients with known or suspected intestinal strictures
Gastrointest Endosc
(2011) - et al.
Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy
Gastrointest Endosc
(2008) - et al.
Prediction of patency capsule retention in known Crohn's disease patients by using magnetic resonance imaging
Gastrointest Endosc
(2016) - et al.
Use of the Given® Patency System for the screening of patients at high risk for capsule retention
Dig Liver Dis
(2006) - et al.
Small-bowel imaging in Crohn's disease: a prospective, blinded, 4-way comparison trial
Gastrointest Endosc
(2008) - et al.
What we have learned from 5 cases of permanent capsule retention
Gastrointest Endosc
(2006) - et al.
How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center
Gastrointest Endosc
(2008) - et al.
Sequential capsule endoscopy of the small bowel for follow-up of patients with known Crohn's disease
J Crohns Colitis
(2014) - et al.
Double-balloon endoscopy as the primary method for small-bowel video capsule endoscope retrieval
Gastrointest Endosc
(2010)
Diagnostic yield and therapeutic implications of capsule endoscopy in obscure gastrointestinal bleeding
Gastroenterol Clin Biol
Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases
Gastroenterology
Frequency and clinical outcome of capsule retention during capsule endoscopy for GI bleeding of obscure origin
Gastrointest Endosc
Complications, limitations, and failures of capsule endoscopy: a review of 733 cases
Gastrointest Endosc
A prospective study of the utility of abdominal radiographs after capsule endoscopy for the diagnosis of capsule retention
Gastrointest Endosc
Retention of the capsule endoscope: a single-center experience of 1000 capsule endoscopy procedures
Gastrointest Endosc
The role of capsule endoscopy in obscure gastrointestinal bleeding
Arab J Gastroenterol
Small bowel capsule endoscopy vs conventional techniques in patients with symptoms highly compatible with Crohn's Disease
J Crohns Colitis
Complications, limitations, and failures of capsule endoscopy: a review of 733 cases
Gastrointest Endosc
Capsule endoscopy in patients with chronic abdominal pain
Dig Liver Dis
Wireless capsule endoscopy
Nature
ICCE consensus for obscure gastrointestinal bleeding
Endoscopy
Operating characteristics of a rank correlation test for publication bias
Biometrics
Bias in meta-analysis detected by a simple, graphical test
BMJ
Increased diagnostic yield of capsule endoscopy in patients with chronic abdominal pain
PLoS One
Can we predict spontaneous capsule passage after retention? A nationwide study to evaluate the incidence and clinical outcomes of capsule retention
Endoscopy
The utility of capsule endoscopy and its role for diagnosing pathology in the gastrointestinal tract
Am J Surg
Small bowel capsule endoscopy for management of Crohn's disease: a retrospective tertiary care centre experience
Dig Liver Dis
Clinical usefulness of novel tag-less Agile patency capsule prior to capsule endoscopy for patients with suspected small bowel stenosis
Dig Endosc
Clinical relevance of patency capsule combined with abdominal ultrasonography to detect small bowel strictures
Eur J Gastroenterol Hepatol
Effectiveness of using low-dose computed tomography to assess patency in gastrointestinal tracts with a patency capsule
Hepatogastroenterology
Retained capsule endoscopy in a large tertiary care academic practice and radiologic predictors of retention
Inflamm Bowel Dis
Video capsule endoscopy—preliminary experience in university hospital setting [in Croatian with English abstract]
Acta Med Croatica
Capsule endoscopy for diagnosis of small bowel tumors: a single-center experience with 21 consecutive patients
Acad J Sec Mil Med Univ
Diagnostic yield and clinical management after capsule endoscopy in daily clinical practice: a single-center experience
Hippokratia
A pilot study of capsule endoscopy for the diagnosis of radiation enteritis
Hepatogastroenterology
Lessons from Korean capsule endoscopy multicenter studies
Clin Endosc
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DISCLOSURE: L. Gerson is a consultant for Capsovision, Inc and Olympus. All other authors disclosed no financial relationships relevant to this publication.
See CME section; p. 1284.
If you would like to chat with an author of this article, you may contact Dr Gerson at [email protected].