Original ArticlesAbdominal Pain-Associated Functional Gastrointestinal Disorder Prevalence in Children and Adolescents with Celiac Disease on Gluten-Free Diet: A Multinational Study
Section snippets
Methods
This international cohort study was conducted during 2014-2015 at 3 university hospitals in 3 cities: Chicago (US) and Messina and Verona (Italy). The study included 3 groups of 4- to 18-year-old children and adolescents: (1) children with CD on a GFD for more than 6 months; (2) sibling controls without CD; and (3) unrelated controls. The Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III (QPGS-RIII) was completed for each subject who consented to the study. The QPGS-RIII has been
Results
A total of 289 children participated in the study (96 with CD on a GFD, 96 sibling controls, and 97 unrelated controls); 53 subjects were recruited into each group from Chicago, 43 subjects were recruited into the CD and sibling groups from Italy, and 44 subjects were recruited into the unrelated control group from Italy (Table I). One subject in the Italian group with CD and their corresponding sibling were excluded because they were older than 18 years. The mean age of subjects in the groups
Discussion
This study investigated the prevalence of chronic AP and AP-FGIDs in children with CD on a GFD, sibling controls, and unrelated controls. We found no significant difference in prevalence in chronic AP or AP-FGIDs among children in the 3 groups. The relative risk of AP-FGIDs in CD compared with siblings was not significant. The relative risk of AP-FGIDs in CD compared with healthy controls, although it exceeded 4-fold, had a CI that crossed 1 and did not achieve significance. The findings of
References (41)
- et al.
Abdominal pain and irritable bowel syndrome in adolescents: a community-based study
J Pediatr
(1996) - et al.
Prevalence of functional gastrointestinal disorders in school-aged children in El Salvador
Rev Gastroenterol Méx
(2015) - et al.
Postinfectious irritable bowel syndrome
Gastroenterology
(2009) - et al.
Salmonella gastroenteritis during childhood is a risk factor for irritable bowel syndrome in adulthood
Gastroenterology
(2014) - et al.
Sa1995 the prevalence of irritable bowel syndrome-like symptoms in pediatric inflammatory bowel disease
Gastroenterology
(2015) - et al.
Abdominal pain and functional gastrointestinal disorders in children with celiac disease
J Pediatr
(2013) - et al.
Characteristics of adult celiac disease in the USA: results of a national survey
Am J Gastroenterol
(2001) - et al.
Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders
Gastroenterology
(2009) - et al.
A prospective school-based study of abdominal pain and other common somatic complaints in children
J Pediatr
(2009) - et al.
Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria
J Trop Pediatr
(2011)
Rome III criteria in parents' hands: pain-related functional gastrointestinal disorders in community children and associations with somatic complaints and mental health
Eur J Gastroenterol Hepatol
Prevalence of functional gastrointestinal disorders in school children in Ecuador
J Pediatr Gastroenterol Nutr
Prevalence of functional gastrointestinal disorders in Colombian school children
J Pediatr
Abdominal pain predominant functional gastrointestinal disorders in adolescent Nigerians
J Pediatr Gastroenterol Nutr
Interpretability of the PedsQL™ Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in pediatric patients with functional and organic gastrointestinal diseases
J Pediatr Psychol
Construct validity of the pediatric Rome III criteria
J Pediatr Gastroenterol Nutr
Annual costs of care for pediatric irritable bowel syndrome, functional abdominal pain, and functional abdominal pain syndrome
J Pediatr
A million-dollar work-up for abdominal pain: is it worth it?
J Pediatr Gastroenterol Nutr
Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009
Neurogastroenterol Motil
Post-infectious functional gastrointestinal disorders in children
J Pediatr
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The authors declare no conflicts of interest.