American Association of Endocrine SurgeonsComparison of tumor markers for predicting outcomes after resection of nonfunctioning pancreatic neuroendocrine tumors
Section snippets
Methods
The databases of NorthShore University Health System, Northwestern Feinberg School of Medicine/Jesse Brown VA Medical Center, University of Chicago Medical Center, and Rush University Medical Center were reviewed to identify patients who had pancreatectomy for nonfunctioning PNETs between 1998 and 2011. Institutional research board approval was obtained from each institution. Chart reviews were performed, and data were collected regarding patient demographics, mode of presentation, type of
Clinicopathologic characteristics
A total of 128 patients with an age (±SD) of 55 ± 14 years were included in this series. There were 71 males and 57 females. The median patient follow-up was 33 months. Forty-two patients (33%) had undergone a pancreatectomy, 78 (61%) had a distal pancreatectomy, 2 (1%) had an enucleation, and 6 (5%) had a central pancreatectomy. The tumor size was 3.3 ± 2.0 cm, and 56 patients (44%) had a tumor less than or equal to 2 cm. The tumor grade was based on mitotic rate and histologic appearance: 73
Discussion
Finding a cost-effective, reliable preoperative marker of malignant behavior in patients with non-functioning PNETs would be very important to optimize their care. An ideal marker would be one that can be obtained preoperatively and be tested with relative ease without subjectivity. This marker, when detected, should predict the risk of distant metastasis and death with high specificity. The marker would need to be easily obtained (serum or tissue based), reliable, cost-effective, and better
References (21)
- et al.
Proposed histopathologic grading system derived from a study of KIT and CK19 expression in pancreatic endocrine neoplasm
Hum Pathol
(2011) c-Kit expression in human normal and malignant stem cells prognostic and therapeutic implications
Leuk Res
(2009)- et al.
Clinical and prognostic significances of nuclear and cytoplasmic KIT expressions in extrahepatic bile duct carcinomas
Mod Pathol
(2007) - et al.
Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients
Mod Pathol
(2010) - et al.
Predicting aggressive behavior in nonfunctioning pancreatic neuroendocrine tumors
Surgery
(2013) - et al.
Lymph nodes and survival in pancreatic neuroendocrine tumors
Arch Surg
(2012) - et al.
Surgical strategies and predictors of outcome for malignant neuroendocrine tumors of the pancreas
J Gastroenterol Hepatol
(2007) - et al.
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
Nat Med
(1997) - et al.
Prognostic relevance of survivin in pancreatic endocrine tumors
World J Surg
(2012) - et al.
Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine tumors
Am J Surg Pathol
(2004)
Cited by (0)
- a
Department of Surgery, NorthShore University HealthSystems, Evanston, IL
- b
Northwestern University Feinberg School of Medicine/Jesse Brown Medical Center, Chicago, IL
- c
University of Chicago, Chicago, IL
- d
Rush University Medical Center, Chicago, IL