22nd Congress of the Latin American Transplantation SocietyLiver transplantationCorrelation Between Functional Capacity and Respiratory Assessment of End-Stage Liver Disease Patients Waiting for Transplant
Section snippets
Methods
This was a prospective study performed at the Liver Transplantation Unit of UNICAMP. This study was approved by the Research Ethics Committee of UNICAMP under process 922/2009, and the subjects gave a formal consent. We included chronic liver disease patients of both sexes, above 18 years old. We excluded those who were unable to understand verbal commands and those diagnosed with acute liver failure.
After the initial assessment and medical history of 46 subjects, we performed maximal
Results
We evaluated 46 patients with end-stage liver disease; 11 were female and 35 were male. The demographic features and clinical outcomes of the population are described in Table 1. The data mean and standard deviation of the ratings are as follows: PFT (%): FVC, 86.76 ± 15.90; FEV1, 86.04 ± 18.83; FEF25-75, 91.26 ± 38.37; MIP, 92.28 ± 44.57; MIP predicted, 102.8 ± 13.8; MEP, 107.39 ± 41.82; MEP predicted, 109.3 ± 18.2; 6MWT (m), 464 ± 76.85. SF-36: FC, 62.3 ± 26.6; PA, 51 ± 38.2; P, 62 ± 28.8;
Discussion
The changes that commonly affect the quality of life of patients with chronic liver disease, such as malnutrition, sarcopenia, and fatigue, are described in the literature. However, it is necessary to study respiratory changes that may be present in this population, whether in strength or in lung volumes and capacities, in order to develop rehabilitation protocols to prevent pulmonary complications after transplantation.
In our study we observed that patients had a mean BMI of 28.68, which does
References (21)
- et al.
Fatigue and physical function after orthotopic liver transplantation
Liver Transpl
(2002) - et al.
Cost-effectiveness of liver transplantation team. Assessing health-related quality of life pre- and post-liver transplantation: a prospective multicenter study
Liver Transpl
(2002) - et al.
Validation of 20-meter corridor for the 6-minute walk test in men on liver transplantation waiting list
Transpl Proc
(2011) Chronic liver disease and health-related quality of life
Gastroenterology
(2001)- et al.
Quality of life, depression, and psychosocial characteristics of patients awaiting liver transplants
Transplant Proc
(2012) - et al.
Respiratory mechanics in patients with tense cirrhotic ascites
Eur Respir J
(1997) - et al.
Evaluation of physical capacity and nutritional status in liver transplant candidates
Rev Assoc Med Bras
(2003) - et al.
Reference values for lung function tests. I. Static volumes
Braz J Med Biol Res
(1999) - et al.
Nutritional assessment in cirrhotic patients: an objective, subjective or multicompartmental approach?
Arq Gastroenterol
(2006) - et al.
Effects of abdominal distension by ascites on lung volumes and ventilation
Arch Intern Med
(1954)
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Supported by FAPESP number 2010/19326-5, until 2013/07/31.