Journal Information
Vol. 82. Issue 4.
Pages 337-338 (October - December 2017)
Vol. 82. Issue 4.
Pages 337-338 (October - December 2017)
Clinical image in Gastroenterology
Open Access
Incidental endoscopic diagnosis of gastric metastases from cutaneous melanoma
Diagnóstico endoscópico incidental de metástasis gástrica por melanoma cutáneo
I.J. Bercholc-Urinowskya,
Corresponding author

Corresponding author at: Sur 132, Colonia Las Américas, Mexico City, Mexico. Tel.:+5215530317924.
, G. Aristi-Uristab,c, M. Shueke-Essesd
a Unidad de Pediatría, Hospital Central Sur de Alta Especialidad de Petróleos Mexicanos, Mexico City, Mexico
b Departamento de Patología, Hospital General de México, Mexico City, Mexico
c Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
d Servicio de Endoscopia, Centro Médico ABC, Mexico City, Mexico
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The stomach is the most common site of metastasis to the gastrointestinal tract from cutaneous melanoma, but the clinical diagnosis is made in less than 5% of those patients. We present herein the case of a 67-year-old man that had undergone wide local excision of an invasive ulcerated melanoma on the back (Clark III, Breslow 1.8mm, stage IIIB) 2 years prior, with positive sentinel lymph node biopsy. He also had complete left axillary lymph node dissection and radiotherapy in the same lymph node area. After presenting with painless episodes of lower gastrointestinal bleeding, the patient underwent esophagogastroduodenoscopy. In the medical interview, he did not complain of other abdominal symptoms. Colonoscopy was normal, with the exception of internal hemorrhoids. The esophagogastroduodenoscopy incidentally revealed multiple melanocytic lesions of different sizes, some of which were ulcerated, with no signs of active bleeding. There were no lesions in the pylorus or duodenum (figs. 1–3). Numerous biopsies were sent to the pathology department, which confirmed the diagnosis of gastric metastasis from cutaneous melanoma (figs. 4–5). At the time of the finding, the patient already presented with CNS invasion and perigastric, hepatogastric, peripancreatic, celiac, and para-aortic adenopathies. He received medical oncologic systemic treatment, but due to disease extension and progression, outcome was unfavorable.

Figure 1.

Gastroesophageal junction with single melanocytic lesion with irregular edges.

Figure 2.

Body of the gastric mucosa with multiple melanocytic lesions of different sizes.

Figure 3.

Image in retroversion, ulcerated neoplastic lesion.

Figure 4.

Oxyntic gastric mucosa. Partial infiltration with loss of architecture of the foveolae and glands from neoplastic cells with a diffuse, discohesive pattern.

Figure 5.

Large neoplastic cells with atypical nuclei with macro-nucleolus and abundant clear or eosinophilic cytoplasm with cytoplasmic melanin.

Ethical disclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that no patient data appear in this article.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Financial disclosure

No financial support was received in relation to this article.

Conflict of interest

The authors declare that there is no conflict of interest.

Please cite this article as: Bercholc-Urinowsky IJ, Aristi-Urista G, Shueke-Esses M. Diagnóstico endoscópico incidental de metástasis gástrica por melanoma cutáneo. Revista de Gastroenterología de México. 2017;82:337–338.

Copyright © 2017. Asociación Mexicana de Gastroenterología
Revista de Gastroenterología de México
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