Journal Information
Vol. 79. Issue 4.
Pages 294-295 (October - December 2014)
Vol. 79. Issue 4.
Pages 294-295 (October - December 2014)
Clinical image in gastroenterology
Open Access
The sign of Leser-Trélat associated with rectal carcinoma
Signo de Leser-Trélat con carcinoma de recto
P. Martínez-Hernández Magro
Corresponding author

Corresponding author: Guadalupe 205-202, Col. Centro. CP 38000. Celaya Guanajuato. Mexico. Phone: +52 (461) 6162123.
, J.J. Jaime Báez-García, J. Báez-Aviña
Departamento de Cirugía de Colon y Recto y Departamento de Dermatología, Hospital Guadalupano de Celaya, Celaya Guanajuato, Mexico
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The sign of Leser-Trélat is characterized by the sudden manifestation and rapid growth in size and number of multiple seborrheic keratoses, related to an underlying neoplasia. A 57-year-old man, with a 4-month progression of changes in bowel habit, complained of thin stools and occasional rectal bleeding; one year earlier, an increasing number of skin lesions suddenly appeared on his back. Colonoscopy revealed a circumferential lesion 13cm from the anal margin (Fig. 1) and the histopathologic study reported adenocarcinoma. Multiple dermal lesions appeared on the patient's back (Fig. 2); they were biopsied, and the reported result was seborrheic keratosis (Fig. 3).

Figure 1.

Colonoscopy showing a friable lesion with irregular edges, 13cm from the anal margin, with a histopathologic diagnosis of adenocarcinoma.

Figure 2.

Dermal lesions on the back (seborrheic keratoses).

Figure 3.

Biopsy of the lesions corroborating seborrheic keratosis.


The sign of Leser-Trélat is defined as the abrupt appearance and rapid increase in size or number of multiple seborrheic keratoses associated with a cancer. The sudden presentation of a large number of pigmented seborrheic keratoses should alert the clinician to rule out other entities and associations with neoplasia. Diagnosis of the skin lesions is confirmed through biopsy.

Financial disclosure

No financial support was received in relation to this article.

Conflict of interest

The authors declare that there is no conflict of interest.

Please cite this article as: Martínez-Hernández Magro P, Jaime Báez-García JJ, Báez-Aviña J. Signo de Leser-Trélat con carcinoma de recto. Revista de Gastroenterología de México. 2014;79:294–295.

Copyright © 2014. Asociación Mexicana de Gastroenterología
Revista de Gastroenterología de México
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