Journal Information
Vol. 83. Issue 4.
Pages 455-456 (October - December 2018)
Vol. 83. Issue 4.
Pages 455-456 (October - December 2018)
Clinical image in Gastroenterology
Open Access
Severe esophagitis due to pinaverium bromide
Esofagitis severa por bromuro de pinaverio
K. Avendañoa, A. Calleria, N. Gonzáleza,b,
Corresponding author

Corresponding author. Department of Gastroenterology. Hospital de Clínicas. Av Italia 2870-Piso 4 Montevideo 11600, Uruguay, Fax: +598-2-4808472
a Gastroenterology Clinic, Hospital de Clínicas, School of Medicine, Montevideo, Uruguay
b Endoscopy Service, Hospital Británico, Montevideo, Uruguay
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A 31-year-old female engineer had an unremarkable personal and family medical history. She sought medical attention due to intense, burning, and incessant pain in the epigastrium at the level of the chest of 24-h progression. The patient stated she had taken an oral dose of 200mg/day of pinaverium bromide for 5 days due to the recent diagnosis of irritable bowel syndrome. She did not present with heartburn or regurgitation and had taken no other medicines or caustic agents. Pain of cardiac origin was ruled out and upper gastrointestinal endoscopy was ordered. That study revealed severe esophagitis at the distal level, with normal gastric mucosa (fig. 1).

Figure 1.

Upper GI endoscopy showing congestion and circumferential sloughing of the entire mucosa of the distal third of the esophagus.


The anatomopathologic study reported severe esophagitis, with necrosis and ulceration of the epithelium and leukocytic infiltrate (fig. 2).

Figure 2.

Permeation of polymorphonuclear neutrophils and areas of necrotized epithelium.


Esophagitis caused by pinaverium bromide ingestion was highly suspected and the treatment was suspended, resulting in rapid symptomatic improvement. At one month, control upper gastrointestinal endoscopy revealed complete healing of the mucosa (fig. 3).

Figure 3.

Control upper GI endoscopy showing esophageal mucosa with no lesions.


Esophageal lesions induced by pinaverium bromide are a little-known complication. Isolated cases have been reported.1–3 However, because the medication is frequently used, it is important to be aware of its possible lesion-producing association, as illustrated by the present case.

Financial disclosure

No specific grants were received from public sector agencies, the business sector, or non-profit organizations in relation to this study.

Conflict of interest

The authors declare that there is no conflict of interest.

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Esophageal damage caused by pinaverium bromide.
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Please cite this article as: Avendaño K, Calleri A, González N. Esofagitis severa por bromuro de pinaverio. Revista de Gastroenterología de México. 2018;83:455–456.

Revista de Gastroenterología de México
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